One RNA,
Two Coordinated Actions
Orchestra RNA Platform
A single engineered construct expresses a tumor-specific antigen to mobilize the immune system — while an antisense module silences the gene driving the tumor. Two mechanisms, composed into one molecule.
HOW IT WORKS
The construct expresses a tumor-specific antigen to activate immunity, while a paired antisense module silences the gene driving the tumor.
ACTION ONE
Tumor-specific antigen
expression
The open reading frame produces a tumor-associated antigen, flagging cancer cells for the immune system.
ACTION TWO
Target gene silencing
A paired antisense module knocks down the driver gene, cutting off the tumor’s growth signal.
THE ORCHESTRA PLATFORM
One RNA, Two actions
A single molecule makes the protein a cell needs, while silencing the gene that drives disease.
Expression
Target delivery
Coding ORF
RNA
ONE MODULE
SILENCING
Silences a gene
Antisense module
THE SCIENCE
Biology behaves like an ensemble. We learened to conduct it.
A therapy succeeds only when sequence, chemistry, and delivery are in tune. Our platform treats them as a single system co-designing each part against the others so potency, durability, and tolerability move together rather than in trade-off.
The result is a repeatable way to compose RNA medicines across tissues from liver to the central nervous system with predictable performance.
